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phenobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may perhaps raise the metabolism of ifosfamide to its active alkylating metabolites.Routine Forming. Phenobarbital could be habit forming. Tolerance and psychological and Bodily dependence might occur with conti